This book presents the culmination of a 14-year pathbreaking research project examining the risks of civilisation collapse and potential solutions to avoid such an outcome. A profound diagnosis reveals that the root issue lies in the widening rift between the hard and social sciences, which have proven largely ineffective at managing the deficiencies of the former. Of course, the prevailing strategies, structures, and human resource management processes of modern nations have also played a significant role in destabilising societies. In economics, we still operate on principles of partial and general equilibrium, whereas we urgently need to adopt the global equilibrium framework proposed here. As things stand currently, we face two major failings in confronting this crisis. First, we lack the knowledge to overcome the existential threats before us. Second, the forces calling for change have adopted inadequate strategies, organisations, and leadership compared to the well-oiled machinery of the status quo. What we need is to jointly develop the missing knowledge and use it to take appropriate action, beginning with the creation of a new discipline, Global Science, to make sense of it all.